In 2010, there were 142,570 estimated new cases of colorectal cancer that led to an estimated 51,370 deaths, making it the third-leading cause of cancer death among men and women. Of the 142,570 ...

A number of studies have investigated the relationship between thymidylate synthase (TS) expression and survival in colorectal cancer (CRC) patients. Although most have reported poorer overall and ...

Breast Cancer Consensus Meetings: Vive la Difference? PURPOSE: We studied the prognostic value of thymidylate synthase (TS) expression in primary colorectal cancer (CRC) and the role of TS expression ...

Thymidylate synthase (EC 2.1.1.45; TS) is the enzyme responsible for the synthesis of thymidine monophosphate (TMP) in the de novo biosynthetic pathway. TS catalyzes the reductive methylation of ...

High expression of thymidylate synthase (TS) and inactivation of p53 are allegedly associated with chemoresistance. The authors evaluated TS and p53 expression in gastric cancer treated with ...

Kinetoplastid and apicomplexan parasites include protozoans which are responsible for human diseases, and cause a serious impact on human health and the socioeconomic growth of developing countries.

Doctors often use chemotherapy to treat NSCLC. Pemetrexed and cisplatin are drugs that may be used. Thymidylate synthase (TS) is a substance that the body produces naturally. Cancer cells need TS to ...

Polyglutamated MTX also inhibits thymidylate synthetase (TYMS), which converts deoxyuridylate to deoxythymidylate in the de novo pyrimidine biosynthetic pathway.

Doctors often use chemotherapy to treat NSCLC. Pemetrexed and cisplatin are drugs that may be used. Thymidylate synthase (TS) is a substance that the body produces naturally. Cancer cells need TS to ...

In the analysis, the researchers assessed expression of P53, SMAD4, thymidylate synthetase (TS), and hTERT; mutations of KRAS and BRAF; microsatellite instability (MSI); and 18qLOH.A total of 1564 ...