Combining an existing small-molecule protein therapy called tumor necrosis factor related apoptosis-inducing ligand (TRAIL) ...

In human epidermis, the molecular events that orchestrate cell death leading to proper barrier formation by the stratum corneum must be properly timed and coordinated for terminal differentiation ...

We used TRA-8 to examine the cell-surface expression of DR5 in a panel of human tumor cells and to determine the susceptibility of these cells to both TRAIL- and TRA-8–mediated apoptosis.