However, Six1 has been shown as a suppressor of the TRAIL-mediated apoptosis by earlier research. 66 More importantly, miR-185 can sensitize Six1-overexpressing resistant cancer cells to TRAIL ...

Dr. El-Deiry's group had previously established that c-Myc is a key mediator of TRAIL-induced apoptosis and that cancer cells lacking c-Myc and a functional apoptotic pathway were resistant to TRAIL.

Preclinical data indicate that rhApo2L/TRAIL can induce apoptosis in a broad range of human cancer cell lines while sparing most normal cell types. In vitro, and in various in vivo tumor xenograft ...

Second, preclinical experiments utilizing TRAIL mutants that selectively bind either TRAIL-R1 or TRAIL-R2 have suggested that TRAIL-R2 might be the more potent receptor for ligand-induced apoptosis of ...

Increasing attention has been focused on the use of agonistic monoclonal antibodies against TNF-related apoptosis-inducing ligand (TRAIL) death receptors DR4 or DR5 as a potential cancer treatment ...

Kazia Therapeutics (NASDAQ:KZIA) on Wednesday reported preliminary results from the first patient in its Phase 1b trial ...

Apoptosis, a key process in the development of embryonic tissue differentiation, later helps to regulate the normal cellular life cycle by destroying damaged cells. When something goes awry, too ...

Pitt Street Research sees strong upside in Prescient Therapeutics as one of the most advanced oncology companies on the ASX .

A new study by researchers at the Icahn School of Medicine at Mount Sinai, Memorial Sloan Kettering Cancer Center, and ...

Department of Radiation Oncology, Division of Radiation Biology, 1530 3rd Avenue South, WT1 674, Birmingham, AL 35294-6832, USA. [email protected] Department of Medicine, Division of Hematology ...