Apoptosis, a process important ... of the relevant pathways by external ligands. One pathway of extrinsic signaling occurs through Apo2L/TRAIL which activates death receptors (DR) 4 and 5.

H-9 cells were resistant to both TRAIL and TRA-8–mediated apoptosis, indicating a blockade of intracellular anti-apoptosis pathway(s) (data not shown). Figure 2: Cell-surface expression of DR5 ...