Apoptosis, a process important ... of the relevant pathways by external ligands. One pathway of extrinsic signaling occurs through Apo2L/TRAIL which activates death receptors (DR) 4 and 5.

The TRAIL variant activates the death receptor (DR) pathway in cancer cells to cause additional apoptosis, maximising the killing power of the NK cell therapy. ONK designed its optimised affinity ...

Despite advancements in melanoma therapy, the prognosis remains unfavorable for many patients. The proteasome inhibitor MG132 has shown therapeutic potential through pathway regulation, yet its ...