Scientists at Zhengzhou University and affiliated organizations synthesized and optimized a series of thienopyridine indole derivatives leading to the identification of compound [I] as the lead ...

Biotechnology and pharmaceutical industry veteran, Abizer Gaslightwala, shares his vision for Akari moving forwardAccess the video hereBOSTON and ...

Finally, the efficacy of SIRT2 inhibitors has recently been investigated in models of Parkinson's disease 149, and beneficial effects correlate with increased acetylation of α-tubulin and ...

Its mode of action is distinct from other tubulin inhibitors and involves binding to specific sites on the growing positive ends of microtubules to inhibit their growth. Recent data for blood ...

CKD’s NHA inhibitors address the limitations of hydroxamic ... disease induces HDAC6 expression and thereby reduces tubulin acetylation. In preclinical animal studies, CKD-510 restored tubulin ...