Their results show that in the absence of γ-secretase activity, the intracellular trafficking of the melanin-producing enzyme tyrosinase to melanosomes stops, preventing pigment production. Tyrosinase ...

"Our goal was to understand how cyclo(L-Pro-L-Tyr) disrupts tyrosinase activity," explained Dr. Furuyama. "In melanin biosynthesis, tyrosinase initially converts L-tyrosine (L-Tyr) to ...

Brooks' previous studies have shown that nitisinone has no effect in OCA-1A, where there's no tyrosinase to stabilize, and OCA-3, where a different part of the melanin pathway is affected, so his ...

Brooks' previous studies have shown that nitisinone has no effect in OCA-1A, where there's no tyrosinase to stabilize, and OCA-3, where a different part of the melanin pathway is affected, so his ...

Tyrosinase initiates the melanin synthesis process. "We previously did not fully understand the role played by this enzyme. In fact, we knew more about the activities of catechol oxidase, ...

Mitogen-activated protein kinase (MAPK) and Wnt signaling pathways are critical for melanocyte development and melanogenesis and could be novel therapeutic targets for modulating melanin synthesis ...

Breakthrough in treatment of melanin-linked skin conditions Over-production of melanin from too much sun exposure can cause skin problems like age spots or liver spots. By Amy Wallace ...

A small pilot clinical study at the National Eye Institute (NEI) suggests that the drug nitisinone increases melanin production in some people with oculocutaneous albinism type 1B (OCA-1B), a rare ...