The changes in the interactions between p53, p63 and p73 isoforms are likely to be fundamental to our understanding in the transition between normal cell cycling and the onset of tumour formation.

Many receptor proteins of the GPCR family exist in multiple isoforms. A comprehensive analysis of different combinations of GPCR isoforms that produce diverse signalling patterns in cells has ...

A new research paper was published in Oncotarget's, titled "Differential silencing of STAT3 isoforms leads to changes in STAT3 activation." ...

Our study identifies thousands of novel brain expressed isoforms, and confirm the importance of alternative splicing in the cortex, dramatically increasing transcriptional diversity and ...

These isoforms have been suggested as the reason for the occasionally observed opposing roles of STAT3 in cancer: an oncogene, on one hand, and a tumor suppressor on the other.