More information: Inbal Shamir et al, Differential silencing of STAT3 isoforms leads to changes in STAT3 activation, Oncotarget (2023). DOI: 10.18632/oncotarget.28412 Journal information: Oncotarget ...

We have approximately 20,000 genes encoded in our DNA sequence, but each gene can be expressed in many different versions—or isoforms—that are generated by a process called 'alternative splicing'.

A comprehensive analysis of different combinations of GPCR isoforms that produce diverse signalling patterns in cells has implications for drug development.

A new research paper was published in Oncotarget's Volume 14 on April 24, 2023, entitled, "Differential silencing of STAT3 isoforms leads to changes in STAT3 activation." ...