Hydroxylation is catalysed by a set of oxygen-dependent enzymes that belong to the 2-oxoglutarate-dependent-oxygenase superfamily, which are, in fact, non-haem, Fe 2+ -dependent enzymes (Box 1).

Researchers defined the structure of a substrate-bound iron 2-oxoglutarate (Fe/2OG) enzyme to explore whether these enzymes could be used to create a wide array of molecules. They saw that Fe/2OG ...

Diiron Enzymes Spark Hydroxylations Diiron monooxygenases join monoiron enzymes in the ability to perform β-hydroxylation of amino acids by Jyllian N. Kemsley ...

In these systems, the enzyme contains two distinct domains: a radical SAM domain responsible for catalysing cyclization and a hydroxylase domain for catalysing hydroxylation.

These enzymes speed up the reaction in each respective step to synthesize serotonin. Scientists have considered hydroxylation by tryptophan and enzyme TPH-1 the standard pathway for several decades.

Researchers at the Max Planck Institute for Chemical Ecology have identified GAME15 as a key protein that regulates the biosynthesis of both steroidal glycoalkaloids and steroidal saponins in plants ...

The flexible new method, for "directed C—H hydroxylation with molecular oxygen," does what only natural enzymes have been able to do until now. It's described in a paper this week in Science.

Vitamin D and magnesium are essential for bone health, immune function, and cardiovascular health. Vitamin D aids calcium absorption, while magnesium helps activate and regulate Vitamin D. Together, ...