We could target this interface, specifically between the RNAP, ribosome, and mRNA, with a compound that interferes with the ...

First, three initiation factor proteins (known as IF1, IF2, and IF3) bind to the small subunit of the ribosome. This preinitiation complex and a methionine-carrying tRNA then bind to the mRNA ...

A tiny chemical modification commonly found on messenger RNAs plays a surprisingly large role in how cells respond to stress, according to a study led by Weill Cornell Medicine investigators.

Bin Wu, associate professor in the department of Biophysics and Biophysical Chemistry at the School of Medicine, visited ...

After copying the genetic code, it delivers the instructions to ribosomes inside the ... Once inside, the mRNA reaches endosomes, and a protein complex called V-ATPase breaks open the endosomal ...

The Ribosome Quality Control Complex (RQC) recognizes and destroys incomplete proteins ... The small subunit had gone away; the mRNA had gone away. We thought the ribosome was completely in ...

During translation, multiple ribosomes travel along the nucleic acid chain to build polypeptides that become functional proteins. Occasionally, these molecular decoders pause on the mRNA, either ...

These rRNAs are involved in mRNA binding and decoding ... The rRNA molecules fold into complex secondary and tertiary structures, forming domains and motifs that are essential for ribosome function.

DNA is a complex molecule that consists of two strands coiled ... translation is the process by which the genetic information in mRNA is used to synthesize proteins. Ribosomes read the genetic code in ...

We call this a complementary copy. The newly formed strand of mRNA is now ready to leave the nucleus and travel to the ribosome. After translation, the polypeptide is finally folded into the ...

First, three initiation factor proteins (known as IF1, IF2, and IF3) bind to the small subunit of the ribosome. This preinitiation complex and a methionine-carrying tRNA then bind to the mRNA ...