To study how mTORC1 signaling influenced facial development after the initial feature formation, the researchers activated mTORC1 in cartilage progenitor cells in the KO mice models at E12.5 and saw ...

Role of mTOR signaling in cytotoxic T-cell differentiation The activity of mTOR complexes, mTORC1, and mTORC2, differentially dictates cytotoxic T lymphocyte fate and memory T lymphocyte formation.

This work is published in Nature Aging in the paper, “A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation, and shortened lifespan.