In addition to the dimer, the structure also reveals that the protease's C-terminal leucine residue is "stuffed into the active site," Rice says, effectively turning off the enzyme after it ...

Some of the mystery has been solved with the publication last month of the first high-resolution crystal structure of an intramembrane protease. Yongchen Wang, Yingjiu Zhang, and Ya Ha from Yale ...

Enzymes are molecular machines that carry out the chemical reactions that sustain all life, an ability that has captured the ...

The structure of enzymes determines how they control vital processes such as digestion or immune response. This is because the protein compounds are not rigid, but can change their shape through ...

ACROBiosystems has developed a series of specialized proteases for the screening and validation of ADC linkers, focusing on ...

A new artificial intelligence tool can predict the functions of enzymes based on their amino acid sequences, even when the enzymes are unstudied or poorly understood.

The ORNL-ILL-Georgia State research team used neutron crystallography to probe the structure of HIV-1 protease in complex with the clinical inhibitor Darunavir.

The crystal structure of the XMRV protease differs from the structures of other retropepsins and instead resembles those of pepsin-like enzymes, suggesting that this protease may represent a ...

Biologists have determined the three-dimensional structure of an unusual viral enzyme that is required in the assembly of new viruses. Learning the fundamental mechanisms for how this process ...

In a finding that offers fresh insights into the early evolution of life on Earth, two RIKEN biologists have conducted lab ...

WEST LAFAYETTE, Ind. - Biologists have determined the three-dimensional structure of an unusual viral enzyme that is required in the assembly of new viruses. The Paramecium bursaria chlorella virus ...