The prolactin signaling pathway displays significant crosstalk with the AR signaling pathway in prostate cancer. CRPC is known to continually express AR, ...

Receptors for prolactin, have previously been shown to promote breast cancer cell growth, survival, and differentiation, Dr. Rui explains, through signaling pathways that involve activation of ...

Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev 1998;19:225-268. Crossref ...

Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways. Genes & Development , 2012; 26 (19): 2154 ...

The PI3K-Akt oncogenic signaling pathway in the mammary glands of mice rapidly induces cells in the breast itself to produce prolactin, which leads to breast tissue differentiation, and prolactin ...

Prolactin signaling pathways have been implicated in the growth of certain breast tumors, particularly in cases of hormone receptor-positive cancers. Animal Models: ...

The discovery of CypA's contribution to the development of breast cancer was helped by previous observations of prolactin receptor (PRLr) signaling. ... of the PRL-PRLr-Jak2-Stat5 signaling pathway.

Prolactin treatment did not induce any of the following effects: activation of the mitogen-activated protein kinase or extracellular signal-regulated kinase pathways in HEK293 cells transfected ...

HealthDay News — Prolactin receptor (PRLR) signaling plays a role in expansion of maternal β-cells during pregnancy, according to a study published online May 23 in Diabetes.