An international research team led by the IPK Leibniz Institute has uncovered the molecular mechanisms governing the ...

Cellular pathways can be controlled through proteolysis, which allows rapid responses to changes in the environment. However, proteolysis is irreversible, so it must be carefully regulated. Here ...

Mechanisms of intracellular proteolysis. The discovery of the lysosome (see, for example, Refs 3,4; see also Fig. 1 and Box 1) was a turning point in the studies on protein degradation.Several ...

Proteolysis-targeting chimeras (PROTACs) are bifunctional molecules that leverage the body’s internal protein disposal system to target and degrade disease-causing proteins. Emerged in 2001 ...

Proteolysis describes the breakdown of proteins into smaller units, such as polypeptides or amino acids. Image Credit: Juan Gaertner/Shutterstock.com It is a vital process in humans and animals ...

Why polyQ huntingtin resists proteolysis is unclear. However, caspase-3 activation initiated the cleavage of wildtype N-terminal huntingtin but not of mutant huntingtin, and the presence of mutant ...

Proteolysis-targeting chimeras represent a novel method of reducing kinase function by promoting degradation of the enzyme rather than inhibition, as is the case with tyrosine kinase inhibitors and ...

ARV-766, a proteolysis targeting chimera (PROTAC) androgen receptor (AR) degrader, in metastatic castration-resistant prostate cancer (mCRPC): Initial results of a phase 1/2 study. Authors : Daniel P.

Poster Title: ARV-393, a PROteolysis TArgeting Chimera (PROTAC) BCL6 Degrader, is Efficacious in Preclinical Models of Diffuse Large B-Cell Lymphoma, Nodal T-Follicular Helper Cell Lymphoma, and ...