Mitochondria are cell organelles surrounded by a double membrane. In addition to numerous essential functions in the ...

Mitochondria are cell organelles surrounded by a double membrane. In addition to numerous essential functions in the metabolism of the cell, they also play a key role in the integration of signals ...

This study explores the use of polarized second-harmonic generation (pSHG) to investigate myosin conformation in the relaxed state, differentiating between the actin-available, disordered (ON) state ...

Farnesyl Diphosphate Synthase (FPPS): An enzyme critical to the mevalonate pathway, responsible for the synthesis of farnesyl diphosphate—a key precursor in isoprenoid biosynthesis.

Lorundrostat has 374-fold selectivity for aldosterone-synthase inhibition versus cortisol-synthase inhibition in vitro, an observed half-life of 10-12 hours and demonstrated a 40-70% reduction in ...

The primary endpoint of placebo-adjusted change in systolic BP was significantly lower among participants assigned to lorundrostat, an investigational aldosterone synthase inhibitor, vs. placebo ...