Obesity has reached epidemic proportions worldwide, posing a significant burden on people’s health and on healthcare systems. It is a major risk factor for ...

OrganOx, with its system for actively preserving viable donor tissue ahead of a transplant procedure, has raised $142 million to expand its commercial reach and R&D. | The company said its ...

This adipose tissue dysfunction has shown to be associated with a higher risk of CVD and CKD in obesity and metabolic syndrome. However, little is known about the mechanisms underlying this potential ...

Massive expansion and remodeling of adipose tissue during obesity differentially affects specific adipose tissue depots and significantly contributes to vascular dysfunction and cardiovascular ...

HFD-induced adipose tissue dysfunction in wild-type mice was characterized by reduced expression of lipogenic enzymes in white fatty tissue, larger adipocyte sizes, and increased markers of ...

Synopsis The systemic control of tissue fibrosis by metabolic organs remains poorly understood. This study identifies procollagen C-endopeptidase enhancer-1 (PCPE-1) as an adipokine released from ...

The impact of androgens on immune cells in adipose tissue is therefore very interesting considering the high prevalence of insulin resistance and type-2 diabetes among normal weight women with PCOS.

The researchers conclude that in individuals who are living with obesity, adipose tissue insulin resistance is more severe in men than in women, which may partly explain why T2D is more common in men.

Macrophages are involved in the destruction of invading bacteria, but they also engulf and digest damaged cells and debris such as degraded collagen in adipose tissue during weight gain.

The findings demonstrate that chronic activation of RalA plays a key role in repressing energy expenditure in obese adipose tissue by shifting the balance of mitochondrial dynamics toward excessive ...