Alzheimer's disease (AD) is a debilitating neurodegenerative condition that affects a significant proportion of older people worldwide. Synapses are points of communication between neural cells ...

APOE gene variants linked to metabolic signatures of aging and Alzheimer’s risk “These results demonstrate the context-dependence of the influence of APOE, with ε2 potentially strengthening ...

New research offers clues into how APOE isoforms affect microglia function differently in Alzheimer's disease, leading to strikingly different risk profiles.

The apolipoprotein E (APOE) gene is a major genetic risk factor for Alzheimer's disease. There are three different versions of the APOE protein: APOE2, APOE3, and APOE4.

Different versions of APOE protein have varying effect on microglia in Alzheimer's disease Date: May 27, 2025 Source: King's College London Summary: A new study suggests how APOE2 is protective ...

Researchers at Georgia Tech have uncovered findings with implications for understanding memory and learning, which could lead to restoring memory in Alzheimer's patients.

Vigil Neuroscience reported a strong safety profile and 50% sTREM2 reduction in an early-stage trial for VG-3927, potentially representing a new avenue for treating Alzheimer’s disease.

Switch Therapeutics Inc. has announced its first development candidate, a liver-sparing APOE (apolipoprotein E) RNAi therapy for treatment of Alzheimer’s disease in APOE4 carriers. Switch’s ...

There are three major forms of APOE protein in humans. Compared with the most common version of the protein-;APOE3-;the APOE4 protein increases risk and APOE2 decreases risk for Alzheimer's disease.

It is worth mentioning that APOE genotyping allows the assessment of a patient’s risk for side effects before the start of an anti-amyloid (beta) therapy in Alzheimer's disease (AD).

With further development, the technology could help advance Alzheimer’s disease diagnosis and treatment. Researchers demonstrate exosomes loaded with fluorescent sensors that can pass through the ...