A recent study published in Genes & Diseases reveals a novel role of XPR1 in promoting ovarian cancer growth by regulating autophagy and MHC-I ...

The addition of postsurgical atezolizumab immunotherapy to standard-of-care chemotherapy in patients with stage III deficient DNA mismatch repair (dMMR) colon cancer significantly improved ...

These results demonstrate important dual roles of PAC-1 as an apoptosis inducer and an autophagy modulator in PNET cell lines and suggest the potential for the combination of PAC-1 and sunitinib to ...

Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) being the predominant type. The roles of autophagy and apoptosis in NSCLC present a dual ...

This review will focus on the role of autophagy in cancer, with particular emphasis on recent advances in the field. We will explore how cancer‐driving pathways regulate autophagy activity and discuss ...

Accumulating evidence suggests that autophagy plays a role in thyroid cancer, acting to promote tumor cell viability and metastatic disease through maintenance of cancer stem cells (CSCs), supporting ...

Opening an autophagy window as the apoptosis door starts to close Date: September 24, 2020 Source: Tokyo Medical and Dental University Summary: Researchers have successfully attached the cancer ...

Understanding the interplay between apoptosis and autophagy induced by metformin may identify new targets for cancer therapy, and improve the therapeutic efficiency.

The involvement of apoptosis in cancer was first demonstrated when apoptosis was found to account for the cell death induced during tumour regression in response to radiotherapy (Kerr et al., 1972).