The Beclin 1–interacting complex, a regulatory platform, consists of Beclin 1, BCL-2 family proteins (which inhibit autophagy), the class III phosphatidylinositol 3-kinase (VPS34), and ATG14L ...

Autophagy is an intracellular bulk degradation system that is highly conserved in eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic ...

Lipid kinases are enzymes that play a critical role in both cell signalling and membrane trafficking by phosphorylating lipid ...

In a previous study published in Autophagy, researchers from Doshisha University, Japan, revealed that PARK7/DJ-1—a PD-associated protein renowned for its antioxidative function and ...

Autophagy is a mechanism through which cellular protein is degraded. Selective autophagy had been thought to prevent the onset of diseases, but the state of proteins in which they could be ...

Autophagy, a natural cellular process, recycles damaged components, boosting health and anti-aging benefits. Fasting, ...

Autophagy protein ATG-16.2 and its WD40 domain mediate the beneficial effects of inhibiting early-acting autophagy genes in C. elegans neurons. Nature Aging , 2024; DOI: 10.1038/s43587-023-00548-1 ...

In a previous study published in Autophagy, researchers from Doshisha University, Japan, revealed that PARK7/DJ-1-a PD-associated protein renowned for its antioxidative function and mitochondrial ...

For example, autophagy genes are required for certain types of unconventional secretion of cytosolic leaderless proteins (e.g., interleukin-1β and interleukin-18) 11 and for phagosome and ...

PARK7, a protein linked to Parkinson’s disease, is secreted from cells via an unconventional pathway involving both macroautophagy and chaperone-mediated autophagy (CMA) under oxidative stress.

Proteins are conventionally trafficked and secreted extracellularly via the endoplasmic reticulum-Golgi pathway. Some proteins that bypass this system and use unconventional mechanisms to exit the ...