L655,240 is a BACE1 inhibitor L655,240 is a competitive BACE1 inhibitor in vitro. To identify effective BACE1 inhibitors, we screened compounds from our in-house library using a FRET-based assay.

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Roy agreed that the irreversibility of the APP/BACE1 interaction does limit this assay’s ability to detect normal trafficking. However, he noted that the irreversibility is also a strength of the ...