The vector that transfers the gene therapy into the inner ear is called Anc80L65, which is an AAV first created in the laboratory of Dr. Vandenberghe and was previously shown in mouse studies to ...

Citation: Synthetic viral vector and surgical technique effectively deliver genetic cargo to inner ear in preclinical study (2022, March 15) retrieved 28 May 2025 from https://medicalxpress.com ...

Mass Eye and Ear research shows the viral vector Anc80L65 efficiently transferred genetic cargo into the inner ear of nonhuman primates via a specialized surgical procedure, paving the way for a ...

Efficient gene transfer to the mouse inner ear is achieved with a synthetic adeno-associated viral vector. Efforts to develop gene therapies for hearing loss have been hampered by the lack of safe ...