CONCLUSIONS: This study provides insights into the critical role of mitochondrial 1-carbon metabolism and MTHFD2 in governing the differentiation of CD34-lineage cells into Tfh cells, which ...

This understanding is often used to rationalise why, for example, a tertiary alkyl halide undergoes a S N 1 rection more readily than a primary alkyl halide. Some older organic chemistry textbooks, ...

Due to the significance of organofluorine compounds in disciplines ranging from medicine to agriculture to materials science, the invention of new methods for the creation of carbon–fluorine bonds is ...

Cyclopropyl carbinol derivatives undergo a regio- and stereoselective nucleophilic substitution at the quaternary carbon center, with pure inversion of configuration, to provide the acyclic products ...

But, when it comes to bulky alkyl groups, amines are choosy about the company they keep and have resisted many chemists’ campaigns to form highly hindered tertiary amines.

In the case of alkyl fluorides, several research groups have made advances in preparing α-fluoroaldehydes in which a secondary stereogenic carbon-bearing fluorine sits next to a carbonyl group.