Fragile X disorders include two distinct conditions: fragile X syndrome (the most common single-gene cause of developmental delay and autism) and an entirely separate group of premutation syndromes.

SMC (structural maintenance of chromosomes) protein complexes are ring-shaped molecular motors essential for genome folding. Despite recent progress, the detailed molecu ...

PCAF acetylates RAD51, leading to RAD51 dissociation from chromatin and degradation. This highlights a regulatory role for ...

Mapping how proteins bind to silica nanoparticle interactions using biophysics by Tokyo University of Science edited by Gaby Clark, reviewed by Andrew Zinin Editors' notes ...

GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central physiological role in the regulation of cardiac function in both health and disease and thus represent one of ...

A small molecule binds to an OX2 protein. The new foundation model Boltz-2, developed by researchers at MIT and Recursion, achieves state-of-the-art performance in protein binding affinity ...

Breast cancer is the most frequent malignancy among women worldwide, and all subtypes of breast cancer involve upregulation of the c-Myc gene, making it a compelling therapeutic target. G-rich regions ...

A hallmark feature of intracellular signaling pathways is the existence of molecular switches, proteins that transition between two principal states: ON and OFF. Heterotrimeric Gα:Gβγ guanine ...

In a new study published in Nature Biotechnology titled “Treatment of acute myeloid leukemia models by targeting a cell-surface RNA-binding protein,” researchers from Boston Children’s ...

Extending this discovery recently in Cell, Flynn and colleagues showed that glycoRNAs form highly organized clusters with RNA-binding proteins on the cell surface.

Scientists are seeking ways to tweak γ-secretase activity to turn down production of Aβ while leaving other substrates untouched. In the January 8 Nature Aging online, researchers led by Jee-Yin Ahn ...