The probe exhibits strong fluorescence responses (up to 900%), sub-second kinetics, and high dopamine specificity without coupling to downstream signaling pathways.

Contraction and relaxation of vascular smooth muscle and cardiac myocytes are key physiological events in the cardiovascular system. These events are regulated by second messengers, cAMP and cGMP, in ...

The second messenger cyclic di-AMP (c-di-AMP) plays a pivotal role in bacterial physiology by regulating osmolyte transport, potassium uptake, cell wall integrity and the overall stress response ...

Transforming Growth Factor Beta (TGF‐β) signalling pathways are integral to a wide array of cellular processes, ranging from embryonic development to tissue homeostasis and immune regulation ...

Ascidians (also known as sea squirts) are small marine animals. Ascidian larvae have tadpole-like bodies and swim by beating their tail, but the adults have a vase-like shape, no tail and are attached ...

Xanthomonas campestris pv. campestris (Xcc) is a vascular bacteria pathogen causing black rot in cabbage. Here, the resistance mechanisms of cabbage against Xcc infection were explored by integrated ...

This result suggests that the Gq pathway is activated upon adhesion to cause a Ca 2+ transient in the adhesive papilla. The Gs pathway initiates metamorphosis by activating cAMP synthesis The ...

KEGG pathway commonly enriched include adrenergic signaling in cardiomyocytes, aldosterone synthesis and secretion, apelin signaling pathway, cAMP signaling pathway, circadian entrainment, insulin ...

PDE5A inhibition deactivates multiple hypertrophy signaling pathways triggered by pressure load (the calcineurin/NFAT, phosphoinositide-3 kinase (PI3K)/Akt, and ERK1/2 signaling pathways).

Calmodulin (CaM), by mediating the stimulation of the activity of two adenylyl cyclases (ACs), plays a key role in integrating the cAMP and Ca2+ signaling systems. These ACs, AC1 and AC8, by decoding ...

Membrane receptors, particularly G protein-coupled receptors (GPCRs), are integral to numerous physiological processes. Precise control of the receptor endocytosis is essential for understanding ...