Degradation of cAMP is controlled by the cAMP phosphodiesterase (PDE) enzymes, which catalyse the hydrolysis of the 3′ ester bond of cAMP to form 5′ adenosine monophosphate (AMP).

Being cut off in traffic, giving a presentation or missing a meal can all trigger a suite of physiological changes that allow the body to react swiftly to stress or starvation. Critical to this "fight ...

Validation of cAMP phosphodiesterase-4D7 (PDE4D7) for its independent contribution to risk stratification in a prostate cancer patient cohort with longitudinal biological outcomes.. JCO 35, 5069-5069 ...

Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling. Genetics 171: 1523–1533. PubMed; ...

Phosphodiesterase-4 tones down this pathway by keeping cAMP levels at bay, spurring scientists to try enhancing cognition by attenuating PDE4. However, because the enzyme comes in four subtypes (A-D) ...