Estrogen exposure is a major determinant of the risk of breast cancer. This article reviews how genotoxic, mutagenic metabolites of estrogen and stimulation of tissue growth by the hormone particip ...

Cancer arises from the acquisition of multiple genetic and epigenetic changes in host cells over the span of many years, promoting oncogenic traits and carcinogenesis. Most cancers develop ...

This study is the first to reveal the dual regulatory role of copper metabolism imbalance and cuproptosis in the development ...

For more than 60 years, the chemical induction of tumors in mouse skin has been used to study mechanisms of epithelial carcinogenesis and evaluate modifying factors. In the traditional two-stage ...

Using artificial intelligence, researchers show how γ-secretase recognizes substrates - an important advance for fundamental ...

An alternate carcinogenesis model based on BRAF mutations, microsatellite instability (MSI), and CpG island methylator phenotype status has been proposed, ...

Are CT scans silently triggering a cancer epidemic — or are we being misled by speculative modeling and media-fueled fear? A new article warns of 103,000 additional cancers from diagnostic imaging, ...

Using in vitro studies, the research team has been able to demonstrate how calcitriol, or activated vitamin D3, inhibits arsenic-mediated carcinogenesis in certain types of skin cells known as ...

The pathogenesis of cancer in Barrett's esophagus is multifactorial. Gastroesophageal reflux seems to be important in the initiation of Barrett's esophagus, but its role in promoting ...

At any given time, over 10 trillion microbes call our guts their home. From breaking down nutrients in our food to strengthening our immunity against pathogens, these microbes play an essential ...

Using artificial intelligence, researchers show how γ-secretase recognizes substrates – an important advance for fundamental and translational research.

Possible mechanistic links between obesity, dietary habits and the development of esophageal cancer need to be explored, including the antioxidant effect of vitamins, which might account for their ...