This receptor, which receives signals from the cytokine interleukin 1, is essentially the gatekeeper for celastrol's metabolic actions, the study found.

The results indicate that celastrol effectively attenuated NO and proinflammatory cytokine production via the inhibition of ERK1/2 phosphorylation and NF-κB activation in LPS-activated microglia.

The aim of this review article was to discuss the druggability, molecular targets, and nanocarrier delivery of the natural triterpenoid, celastrol, against chronic diseases. The physicochemical ...

Scientists discover how anti-viral cytokines can blunt the immune response to tuberculosis ...

Celastrol was found to be one of the best-matched drugs that can restrain the release of the virion particles and the secretion of IL-6 by SARS-CoV-2-infected cells.

Three cytokines differentiate latent infection from active Mycobacterium tuberculosis (TB) disease.

Two immune system molecules could form the basis of a new test to quickly detect whether tuberculosis is dormant or active and infectious, U.S. researchers said on Sunday.

Celastrol is an active compound from the root of Tripterygium wilfordii Hook F that shows great potential in the treatment of inflammation, cancer, neurodegeneration, diabetes, and obesity.