Ferroptosis, a form of programmed cell death mediated by iron, has been a focus for its potential in cancer therapies. Now, researchers have discovered that lysosomal lipid peroxidation plays a ...

Septerna's GPCR platform shows promise, but execution risks, funding needs, and competition suggest caution. Click here to ...

The reported cryo-EM imaging of a pentameric ligand-gated ion channel in liposomes as opposed to nanodiscs has both broad implications and contributes valuable methodological advances to the ...

It is mediated by iron molecules, with the cell dying through the degradation of the phospholipid bilayer by oxidation ... a drug that promotes lysosomal membrane damage—facilitates ferroptosis ...

The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is equally important: cell death.

Cells must constantly manage the structure ... a distance that closely resembles their arrangement in natural membrane bilayers. Mass spectrometry identified two co-purifying auxiliary proteins.

Cell biology is the discipline of biological ... proteins function as bridges at contact sites between intracellular membranes to allow bulk flow of phospholipids between them.

Collaboration combines Novo Nordisk's scientific leadership in obesity and cardiometabolic diseases with Septerna's expertise in G protein-coupled receptor (GPCR) drug discovery Goal is to develop mul ...

These models suggest that action potentials are not purely electrical phenomena but also involve mechanical changes in the cell membrane. The soliton model ... moving along the lipid bilayer. As ...