Mitochondria are cell organelles surrounded by a double membrane. In addition to numerous essential functions in the ...

Review Published: 12 April 2004 Role of mitochondrial membrane permeabilization in apoptosis and cancer Judith Henry-Mowatt, Caroline Dive, Jean-Claude Martinou & Dominic James Oncogene 23, 2850 ...

The mitochondrial pathway of cell death, in which apoptosis proceeds following mitochondrial outer membrane permeabilization, release of cytochrome c, and APAF-1 apoptosome-mediated caspase ...

A collaborative study from the University of Cologne has uncovered how a key mitochondrial protein, AIFM1 (Apoptosis-Inducing ...

Results provide new insights for apoptosis research, and could lead to opportunities to explore Bax and its relatives as interesting targets in cancer therapy.

This intricate relationship with cellular functions makes mitochondria central to the study of drug-induced toxic organ injuries, where mitochondrial dysfunction is a key mechanism of harm.

What is the role of mitochondria in brain health? Is there a link between mitochondria and memory? Mitochondria do all kinds of things in the healthy brain.

Mitochondria as a Control in Apoptosis For this article, Jennifer Fisher Wilson interviewed Guido Kroemer, Research Director, Centre National de la Recherche Scientifique, Institut Gustave Roussy in ...

Recent research on MCL-1, a critical protein that is an attractive target for cancer drug development, helps explain why some ...

Role in mitochondrial metabolism paints more complete picture of MCL-1 function Peer-Reviewed Publication St. Jude Children's Research Hospital ...

In particular, mitochondrial Ca 2+ plays a dual role: enabling physiological functions like metabolism and ATP synthesis while contributing to pathological processes such as apoptosis and ...