Caspase-3 is activated in response to serum withdrawal, activation of Fas, treatment with radiation, pharmacological agents, as well as other upstream caspases like caspase-8 and caspase-9.

3.3 Silencing circASH1L attenuated cisplatin resistance by regulating ferroptosis in ovarian cancer cells Given the close relationship between ferroptosis and drug resistance, we investigated the ...

The signaling pathway might be via the activation of caspase-8, increase in mitochondrial tBid, disruption of mitochondrial membrane potential, and translocation of apoptosis-inducing factor (AIF).

Defective RuO 2 Nanospheres Attenuate Osteoarthritis Progression via Suppressing the ROS/NLRP3/Caspase-1 Signaling Pathway ...

Subcellular sequestration of caspase near membrane-associated proteins enables its non-lethal activation, which modulates neuronal function and innate olfactory behavior in the adult Drosophila ...