The research reveals significant reduction in the citric acid cycle intermediates and key enzyme gene expressions by 6-PPDQ exposure, highlighting the its potential exposure risk on citric acid ...

The study reveals how 6-PPDQ at environmentally relevant concentrations (0.1–10 μg/L) disrupted the citric acid cycle by reducing intermediate metabolites, including citric acid, α-ketoglutarate, ...

Secretory progenitors accumulated αKG, exhibited reduced expression of downstream TCA-cycle enzymes, and showed elevated DNA hydroxymethylation at loci associated with secretory fate.

RV‐PA coupling was negatively associated with tricarboxylic acid (TCA) cycle intermediate levels. Specifically, plasma α‐ketoglutarate and fumarate were significantly associated with all coupling ...

But just as important as what you eat is when you eat is also crucial, especially if your nemesis is digestive issues like bloating and acid reflux. For the uninitiated, bloating is the tight ...

The complete targeted profile of the organic acid intermediates of the citric acid cycle using a single stable isotope dilution analysis, sodium borodeuteride reduction and selected ion monitoring ...

Chemistry experts discover how key enzyme in amino acid metabolism works SEPTEMBER 3, 2020 — UTSA researchers have discovered how 3-hydroxyanthranilate-3,4-dioxygenase, an enzyme known as HAO that is ...

Malic acid is a naturally occurring organic compound found in many fruits, especially apples. It is an alpha-hydroxy acid (AHA) known for its role in energy production, digestion, skin health, and ...

Pathway analysis revealed that the citric acid cycle was the most significantly affected, with urinary excretion of citrate, cis-aconitate, isocitrate, 2-oxoglutarate and succinate reduced by 40–68%.

This research sheds light on the complex interactions between nucleic acid sensors and enzymes in immune cells and paves the way for more precise immune therapies.