These are exciting times for biotech business Complement Therapeutics, which stands on the cusp of an important milestone in ...

An international study led by researchers at the University of Colorado Anschutz Medical Campus has identified a promising ...

The immune system has evolved to act as a first responder against infections, and scientists have revealed how it knows when to activate.

A team of scientists has uncovered how an ancient immune system, the complement system, decides when to launch an attack—revealing a hidden mathematical tipping point based on the spatial density of ...

C3G and IC-MPGN are rare kidney conditions. They occur when a part of the immune system, called the complement system, doesn’t work as it should.

Healio: Your findings show that when granzyme K acts on the complement system, it not only drives inflammation, but also recruits immune cells and causes tissue damage. How does that occur?

Harvard Medical School scientists have identified a key protein in the human immune system that drives inflammatory and autoimmune conditions when it turns against the body.

For example, the nervous system can sense changes in the external environment and convey these changes through molecules and mediators with receptors in the immune system to modulate immune responses.

Through a series of experiments, they demonstrated that GZMK activated the entire complement cascade, producing complexities that drive inflammation, recruit immune cells, and cause tissue damage.

Complement proteins also act on one another to activate various forms of complement proteins and to amplify how many complement proteins are activated. This is called a complement cascade and helps to ...

The complement system is a central component of the innate immune system. Constitutive biosynthesis of complement proteins is essential for homeostasis. Dysregulation as a consequence of genetic or ...

Complement responses may contribute to priming of the adaptive immune system or serious adverse events such as hepatotoxicity and thrombotic microangiopathy.