Cardiac sodium–calcium exchanger (NCX1), the dominant calcium (Ca) efflux mechanism in cardiomyocytes, is strongly regulated by pH. However, the physiological relevance of NCX1 pH regulation in ...

School of Mechanical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China Shandong Institute of Mechanical Design and Research, Jinan 250353, China School of ...

Thirty-one members of the University of Chicago faculty have received distinguished service professorships or named professorships. Rishi Arora, Ozan Candogan, Erika Claud, Anthony Fowler, Alexander ...

Abstract: The heart consists of myocytes, vasculature cells and connective tissue cells. In this study, two ventricular electromechanical models were coupled with the fibroblast model. At the cellular ...

This study provides a valuable characterization of individual sarcomere's contractility and synchrony in spontaneously beating cardiomyocytes as a function of substrate stiffness. The authors, however ...

For quantifying the expression of WT and mutant CaM, cell lysate (30 μg protein) were loaded in a Ca 2+-free loading buffer containing 20 mmol/L EDTA and immunoblotted using anti-CaM antibody (1:1000, ...

As we learned at school, adenosine triphosphate (ATP) is the energy currency of all cells in the body. In the heart, it is used to fuel the interactions between actin and myosin which produce ...

Introduction: In 2016 the US government declared opioid misuse a public emergency. While most opioid related deaths can be attributed to overdose, recent data suggest a link between opioid use and ...