A new study published in Biochemistry sheds light on how bacteria regulate their genes, challenging long-held assumptions ...

Being cut off in traffic, giving a presentation or missing a meal can all trigger a suite of physiological changes that allow the body to react swiftly to stress or starvation. Critical to this "fight ...

Elevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF-induced endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1, but not intercellular ...

Chemists synthesize ocean-based molecule that could fight Parkinson's In producing lissodendoric acid A, the team used a method they say may help accelerate the process of drug discovery Date ...

Tsukuba, Japan—Cyclic molecules are used in a wide range of applications, including molecular sensing, because they can incorporate specific molecules of interest into their inner cavities ...

Cyclic peptide drugs have attracted the attention of major pharmaceutical companies around the world as promising alternatives to conventional small molecule-based drugs. Through proper design, cyclic ...

Scientists have developed a computational method based on large-scale molecular dynamics simulations to predict the cell-membrane permeability of cyclic peptides using a supercomputer. Their ...

Earl W. Sutherland Jr., former professor and chair of the Department of Pharmacology, led the discovery of cyclic AMP, a cellular signaling molecule responsible for many metabolic processes. He won ...

“Cyclic AMP can access a more strongly bound state; that is, it stays longer in its binding site on the ion channel, compared with cGMP, suggesting that this deep-bound state is the key to ...

THE biologic role of cyclic AMP (adenosine 3′,5′-monophosphate), at least as it is understood today, is shown in Figure 1. After release from an endocrine gland, a hormone is transported to ...

Additionally, mutants with altered levels of c-di-AMP had different susceptibilities to peptidoglycan-targeting antibiotics, suggesting that the molecule may be involved in regulating cell wall ...