All living organisms encode the amino acid sequences of proteins as nucleotide sequences (genetic information) in their ...

Epigenetics involves a series of biological processes that regulate chromatin-mediated DNA templates. 2 Cancer is a ...

DNA methylation There are three methods of epigenetic changes; histone modification, chromatin remodeling and, the most common, DNA methylation (DNAme). In eukaryotes, DNAme occurs when a DNA ...

DNA methylation is a widely studied epigenetic modification with crucial roles in gene regulation, development, and disease, particularly in cancer. It has immense potential as a biomarker for early ...

See the article: Mechanism studies of the activation of DNA methyltransferase DNMT1 triggered by histone H3 ubiquitination, revealed by multi-scale molecular dynamics simulations.

DNA and RNA methylation, initially thought to operate as distinct pathways, have been shown to interact closely, shifting our understanding of gene regulation. A team of researchers from the ...

Promega’s MTase-Glo, a bioluminescence-based assay, can monitor the activities of methyltransferases and their modulation by small molecules in a wide range of plate formats.

DNMT3a is a de novo DNA methyltransferase expressed robustly after T-cell activation that regulates plasticity of CD4⁺ T-cell cytokine expression. Here we show that DNMT3a is critical for directing ...

Another important DNA damage repair enzyme, MGMT, is involved in direct cleavage of mutagenic alkyl adducts within DNA (direct DNA repair). MGMT loss of expression, almost connected to promoter ...