The findings of this research confirm mutant DNA methyltransferase 3A (DNMT3A) as a potential target for effective blood cancer treatment. One of the most common DNA mutations found in blood ...

Trailhead Biosystems Inc. (TrailBio.com), a biotechnology company pioneering the creation of iPSC-derived human cells at scale for drug discovery and cell therapy, is pleased to announce the ...

Northwestern Medicine investigators have discovered new intracellular mechanisms that help specialized immune cells adapt and ...

DNA methylation, mediated by the DNA methyltransferase (DNMT) family, has long been associated with transcriptional repression or activation, depending on its genomic location. Meanwhile ...

Given its pivotal role in disease, DNA methylation has emerged as a promising therapeutic target, with several DNA methyltransferase inhibitors already approved by the US Food and Drug Administration.

Our group applies structural (cryo-EM, x-ray crystallography and NMR), biochemical and biophysical methods together with functional studies to investigate macromolecular-mediated recognition, ...

Sex differences in traits and disease risk are pervasive and begin before birth. Here, the authors report sex-dependent human placental epigenetic and transcriptomic regulation and highlight its ...

The findings of this research confirm mutant DNA methyltransferase 3A (DNMT3A) as a potential target for effective blood cancer treatment. One of the most common DNA mutations found in blood cancers ...

Osteoarthritis develops slowly over time, and there is currently no cure. Treatments mostly focus on reducing symptoms and ...