A phase 1/2 dose escalation study of the oral DNA polymerase theta inhibitor (POLQi) GSK4524101 ± niraparib in adults with advanced or metastatic solid tumors.. If you have the appropriate software ...

DNA hybridization reaction is a significant technology in the field of semi-synthetic biology and holds great potential for use in biological computation. In this study, we propose a novel machine ...

Mitochondrial DNA (mtDNA) replication is essential for mitochondrial function. This is carried out by a dedicated DNA polymerase gamma, with 5’–3’ polymerase and 3’–5’ proofreading/ exonuclease ...

Since the 1980s, one approach has reigned supreme in this field: chemical DNA synthesis, namely the phosphoramidite method. 2 From primers for driving polymerase chain reaction to guide RNA for CRISPR ...

DNA polymerase θ (Pol θ or POLQ) is primarily involved in repairing double-stranded breaks in DNA through an alternative pathway known as microhomology-mediated end joining (MMEJ) or theta-mediated ...

PCR components, such as template DNA, polymerase, primers, nucleotides and minerals are soluble in water but not oil. This forms the basis for the concept behind emulsion PCR, which is a technique ...

These structures show Pfu DNA polymerase in its natural (left) and mirror-image (right) forms. To synthesize the mirror image polymerase, researchers constructed two fragments (pink and blue) and ...

Researchers show that polymerase theta can efficiently convert RNA sequences back into DNA, a feat more common in viruses than eukaryotic cells.

This polymerase chain reaction allows for the amplification of a single piece of DNA over and over again. This amplification process means that even if only a small amount of the DNA is present in the ...

Geneticist Dr Kat Arney in the latest episode of the Genetics Society’s Genetics Unzipped podcast, brings you the story and the characters behind one of the most transformative and ubiquitous ...