Human eggs are some of the most patient cells in the body, lying dormant for decades until needed. A study published in The EMBO Journal shows that the cells deliberately slow the activity of their ...

Scientists at ChristianaCare’s Helen F. Graham Cancer Center & Research Institute and the University of Delaware have discovered a surprisingly simple explanation for how our bodies stay so ...

Here, we provide evidence that several cell types in culture actually experience local hypoxia, with important implications for cell metabolism and function. We focused initially on adipocytes, as ...

Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) are closely linked to immunogenic cell death (ICD), a process critical for eliciting antitumor immune responses. As one of the ...

The endoplasmic reticulum (ER) is an organelle that has essential roles in multiple cellular processes that are required for cell survival and normal cellular functions.

A team of international researchers led by scientists at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in t ...

A team of international researchers led by scientists at City of Hope ®, one of the largest and most advanced cancer research and treatment organizations in the United States, with its National ...

A team of international researchers led by scientists at City of Hope provide the most thorough account yet of an elusive target for cancer treatment. Published today in Science Advances, the ...

Owing to the toxic potential of unfolded proteins, their accumulation in the endoplasmic reticulum activates a cellular stress response. This unfolded protein response remodels the secretory ...