The authors present an important set of data implicating ETFDH as an epigenetically suppressed gene in cancer with tumor suppressive functions. The evidence is solid, with the authors demonstrating ...

It emerges that the enzyme PLA2G15 breaks down BMP, and inhibiting PLA2G15 extends lifespan in a mouse model of Niemann–Pick type C1, a neurodegenerative disorder marked by impaired lysosomal ...

Several human pathogens exploit the kinetic forces generated by polymerizing actin to power their intracellular motility. Human cell-autonomous immune responses activate ...

A study of human tumor cells implanted in mice from the MacPherson Lab at Fred Hutch describes a new way to screen for the ...

It emerges that the enzyme PLA2G15 breaks down BMP, and inhibiting PLA2G15 extends lifespan in a mouse model of Niemann–Pick type C1, a neurodegenerative disorder marked by impaired lysosomal ...

AMSBIO has introduced a new series of Deubiquitinating (DUB) enzyme assay kits that streamline the analysis of DUB activity in both purified systems and cell-based models. Supplied in a convenient ...