Indeed, electrophilic amide activation relies fundamentally on an increased electron density at the amide oxygen; therefore, in competition with other carbonyls, for example, esters or ketones, there ...

Carbamoyl anions, generated from N,N-disubstituted formamides and lithium diisopropylamide, add with high diastereoselectivity to chiral N-sulfinyl aldimines and ketimines to provide α-amino amides.

Reactions that alter organic scaffolds by a single atom are already proving useful, but time will tell if they’ll ...