In light of the evidence that SYK has been shown to activate mTOR in lymphoma and that mTOR has an important role in AML, we hypothesized that SYK may also regulate mTOR signaling in AML. Here, we ...

The spleen tyrosine kinase Syk has predominantly been studied in hematopoietic cells in which it is involved in immunoreceptor-mediated signaling.

Tyrosine Kinases The transduction of extracellular signals across the membrane to initiate complex cascades of molecular events regulates numerous vital cellular processes. The molecular basis of ...

Spleen tyrosine kinase (Syk) is an important modulator of immune signaling. The objective of this phase 2 study was to evaluate the efficacy and safety of R788, an oral inhibitor of Syk, in patient ...

Tyrosine kinase SYK (spleen tyrosine kinase), an enzyme involved in immune signaling, could play a key role in Alzheimer's disease (AD), multiple sclerosis (MS), and other neurodegenerative diseases, ...