Cell surface receptors belonging to the family of G protein coupled receptors (GPCRs) – also known as seven-transmembrane, heptahelical or serpentine, receptors – are involved in the ...

Now, scientists have developed small proteins to selectively block a certain type of G-protein signaling, creating a unique and powerful tool for studying cell processes that depend on this signaling.

These results show that interference with G-protein function was effective under our experimental conditions and support a mechanism of G-protein-independent signaling by mGluR1. Src-family ...

Syrovatkina V, et al. Regulation, signaling, and physiological functions of G-proteins. J Mol Biol. 2016;428(19):3850-3868. Liccardo F, et al. Endomembrane-based signaling by GPCRs and G-proteins.

Heterotrimeric G proteins are important in G protein-coupled receptor signaling, which is important in the detection of various stimuli. Here, researchers found that the protein that regulates ...

Regulator of G protein signaling (RGS) proteins control signal termination by serving as GTPase accelerating proteins (GAPS); i.e., they increase the rate of GTP hydrolysis by Gα.

The G protein biosensors constitute a GoLogo motif domain of Rap1GAP (interacts with all Gα i/o/z subunits), a regulator of G protein signaling (RGS) domain of p63RhoGEF (interacts with Gα q/11 ...

This important study fills an gap in our knowledge of the evolution of GPCRs in holozoans, as well as the phylogeny of associated signaling pathway components such as G proteins, GRKs, and RIC8 ...

More information: Lijie Liu et al, Redox regulation of G protein oligomerization and signaling by the glutaredoxin WG1 controls grain size in rice, The EMBO Journal (2025). DOI: 10.1038/s44318-025 ...

Scientists have identified how the brain protein cypin helps maintain strong connections between neurons, a discovery with ...