This important study fills an gap in our knowledge of the evolution of GPCRs in holozoans, as well as the phylogeny of associated signaling pathway components such as G proteins, GRKs, and RIC8 ...

These 7 strategic foods helped me stop nighttime overeating—not by adding rules, but by feeding my body what it actually ...

An engineered protein turns off the kind of immune cells most likely to damage tissue as part of type-1 diabetes, hepatitis, multiple sclerosis, shows a new study in mice.

Loss of fine‐tuning of G protein signaling by RGS2 protein attributed to loss‐of‐function mutations or protein degradation in the vasculature could predispose to pregnancy complications, including ...

In particular, several studies have revealed the heterotrimeric guanine nucleotide-binding protein (G protein) signaling plays a crucial role in grain size regulation (Duan and Li 2021; Liu et al, ...

Eating plenty of protein has numerous benefits for weight loss, muscle gain, and health. Here are 10 science-backed reasons to eat more protein.

Signal transduction through G-protein–coupled receptors (GPCRs) is central for the regulation of virtually all cellular functions and has been widely implicated in human disease. Regulators of ...

Capturing the conformational dynamics of GPCRs, describing various functional states, and understanding allosteric mechanisms and their role in G protein selectivity, coupling promiscuity, activation ...

More than a third of FDA-approved drugs work by targeting a G protein-coupled receptor, or GPCR. The human body has more than 800 types of GPCRs that provide cells with information about the ...

PC1 is thought to function as an atypical G protein-coupled receptor, yet the mechanism by which PC1 regulates G-protein signaling remains poorly understood. A significant portion of ADPKD mutations ...