Now, scientists have developed small proteins to selectively block a certain type of G-protein signaling, creating a unique and powerful tool for studying cell processes that depend on this signaling.

Cell surface receptors belonging to the family of G protein coupled receptors (GPCRs) – also known as seven-transmembrane, heptahelical or serpentine, receptors – are involved in the ...

The G protein biosensors constitute a GoLogo motif domain of Rap1GAP (interacts with all Gα i/o/z subunits), a regulator of G protein signaling (RGS) domain of p63RhoGEF (interacts with Gα q/11 ...

Regulator of G protein signaling (RGS) proteins control signal termination by serving as GTPase accelerating proteins (GAPS); i.e., they increase the rate of GTP hydrolysis by Gα.

Oct. 26, 2022 — Researchers have identified a new signaling process involving G protein-coupled receptors (GPCRs), a cellular target already exploited by hundreds of diverse drugs.

More information: Lijie Liu et al, Redox regulation of G protein oligomerization and signaling by the glutaredoxin WG1 controls grain size in rice, The EMBO Journal (2025). DOI: 10.1038/s44318-025 ...

G proteins: Intracellular signaling molecules. Gs, Gq and Gi are among the known types of G proteins. Cell excitation: It is known that β cells, nerve cells and muscle cells are electrically ...

Heterotrimeric G proteins are important in G protein-coupled receptor signaling, which is important in the detection of various stimuli. Here, an Osaka University-led research team found that the ...

O'Neill PR, Karunarathne WK, Kalyanaraman V, Silvius JR, Gautam N. G-protein signaling leverages subunit-dependent membrane affinity to differentially control βγ translocation to intracellular ...