DNA makes RNA, RNA makes protein, protein makes phenotype—was the guiding framework for understanding inheritance and disease ...

The central dogma of molecular biology is linear, moving from DNA to mRNA to protein. It's straightforward on an individual-gene level: turn on a gene, make mRNA, create proteins from the mRNA.

University of Buffalo researchers conducted a systematic analysis of switch-like genes by analyzing genomes, transcriptomes ...

The previous paradigm was given in what is called the central dogma. DNA—> RNA—> Protein—> Phenotype The dogma was enshrined in Jim Watson’s 1965 epic textbook The Molecular Biology of the ...

That could result in the activation of a gene, a halt in gene activity or a sequence that codes for the creation of a ...

Central dogma: The clinical view ... makes it clear that any form of current classical one-by-one gene status assessment will not be adequately informative ... accommodating the actual vast ...

Patients with treatment-resistant central centrifugal cicatricial alopecia saw improvement in symptoms and gene expression, suggesting the potential of metformin as a new treatment option.