The glutathione-dependent system is one of the key systems regulating cellular redox balance, and thus cell fate. Cysteine, typically present in its oxidized form cystine in the extracellular ...

Thioredoxin reductase (TrxR) is similar in activity to glutathione reductase (GR), catalyzing the reduction of GSSG to GSH, and is one of the key enzymes of the glutathione redox cycle.. TrxR is a ...

Glutathione is the most abundant cellular redox buffer that both protects cells from oxidative damage and mediates cellular signaling. Perturbation of glutathione balance has been associated with ...

The intracellular redox potential of the glutathione (GSH)/glutathione disulfide (GSSG) couple regulates cellular processes. In vitro studies indicate that a reduced GSH/GSSG redox potential ...

A multidisciplinary research team reports a FRET-based biosensor with defined sensitivity and dynamic range for imaging changes in the intracellular redox environment that appear to dictate cell fate.

NIST researchers have developed a new method for accurately measuring a key process governing a wide variety of cellular functions that may become the basis for a ,health checkup, for living cells.