Background Restarting direct oral anticoagulants (DOACs) after a serious bleeding event in patients with atrial fibrillation ...

To reduce this period of time, bridging therapy with intravenous unfractionated heparin has typically been given in place of warfarin when the INR falls below a therapeutic level.

These drugs are well tolerated and easy to administer in the outpatient setting; therefore, hospitalization required for the bridging of anticoagulation therapy may be avoided.