By establishing an iron overload-induced hepatic ferroptosis model, scientists from Japan have identified iFerroptosis—an ...

By establishing an iron overload-induced hepatic ferroptosis model, scientists from Japan have identified iFerroptosis-an ...

Here, the authors show that NNMT/1-MNA protects against hepatic ischemia-reperfusion injury by modulating the AKT/FOXO1/ANGPT2/JNK axis.

Bioluminescent imaging is helping researchers better understand the effectiveness of tissue regeneration enhancers delivered to injured heart tissue by different adeno-associated virus vectors.

Background Liver ischemia-reperfusion injury (IRI) refers to the interruption of liver blood supply upon reperfusion, which rapidly leads to liver damage in an antigen-independent way. Almost 50% of ...

The final, formatted version of the article will be published soon. Hepatic ischemia-reperfusion injury (HIRI) is a major complication in liver transplantation, hepatic surgeries, and shock-induced ...

NNMT/1-MNA protects against hepatic ischemia-reperfusion injury through the AKT/FOXO1/ANGPT2/JNK axis Nicotinamide N-methyltransferase (NNMT) and its metabolite 1-MNA have been implicated in liver ...

The pig’s heart was graying rapidly, so McCully decided to try it. He loaded a syringe with the extracted mitochondria and ...

The triggering receptor expressed on myeloid cells 2 (TREM2) plays a pivotal role in the activation of myeloid cells and is currently being investigated as a potential therapeutic target in several ...

Despite upstream recanalization in acute ischemic stroke, it is now increasingly recognized that blood flow may fail to reach downstream tissue microvascular beds in a phenomenon termed “no-reflow”.

Immune disorders are intimately involved in the pathological progression of myocardial ischemia–reperfusion injury (MIRI) and exacerbate cardiac cell damage and mitochondria-related metabolic ...

TGR5 agonists also showed their therapeutic potential for treatment of liver fibrosis, autoimmune hepatitis, hepatitis B, nonalcoholic steatohepatitis, cholestatic and hepatic ischemia-reperfusion ...