A research team led by Prof. Gu Hongcang and Zhang Fan from the Hefei Institutes of Physical Science of the Chinese Academy ...

Glucan-mediated trained immunity activates alveolar macrophages which exacerbates acute lung injury induced by LPS.

Enzyme-linked immunospot assay An ELISpot assay was conducted to verify cellular immune responses. IFN-γ-secreting cells were detected using the Mouse IFN-γ ELISpot Kit (XEL485, R&D System).

IFN-γ response and the relationship between viral diversity and the rate of immune escape in subjects chronically infected with HCV. IFN-γ ELISpot values (SFU/million, right y-axis) and viral load (IU ...

Notably, IFN-γ blockade enables full differentiation of Tcf-1 + cells into T FH cells, formation of germinal centers, and increased antibody production. Suppression of T FH cells by IFN-γ is not ...

Mechanistic studies showed that Lrrk2 promotes macrophage polarization toward the M1 phenotype by enhancing STAT1 phosphorylation in response to IFN-γ signaling.

To corroborate the interferon-γ responses found in patients with APS-1, we performed immunologic evaluations of wild-type and Aire−/− mice and in situ hybridization evaluations of wild-type ...

The following is a summary of "IFN-γ ELISpot-enabled machine learning for culprit drug identification in nonimmediate drug hypersensitivity," published in the January 2024 issue of Allergy & ...

SARS-CoV-2 triggers the production of the antiviral protein IFN-γ, which is associated with fatigue, muscle ache and depression. New research shows that in Long COVID patients, IFN-y production ...

Desmoid tumors are rare, locally aggressive, highly recurrent soft-tissue tumors without approved treatments. We conducted a phase 3, international, double-blind, randomized, placebo-controlled tri ...